gap project portfolio » Cascade Prodrug

Project Title: Nanosystem for the delivery of Hypoxia-Activated-Prodrugs

Prinicipal Investigator: Adam Alani, Oregon State University

Company Principal: August Sick, Cascade Prodrug

Project Description: Cascade Prodrug, working with researchers from Oregon State University, is working to examine the key molecular mechanisms involved in the activation and function of lead anti-cancer compounds, specifically targeting tumor hypoxia using prodrugs.  By selectively targeting tumor hypoxia for activation, the prodrugs are less toxic to nomral cells than the corresponding parent drugs thereby providing a  safer, mor eeffetive cancer treatment.  Data generated in this project will provide Cascade Prodrug with a clear path for drug development, attracting investors who need this critical information in order to provide the capital for Cascade Prodrug to build a product development team in Oregon.

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